High-affinity platelet [3H]LSD binding is decreased in panic disorder

Abstract

Platelet [3H]LSD binding was measured in 15 patients with panic attacks and 15 control. The mean (±SD) Bmax values of the patients (14.1 ±6.3 fmol/mg protein) and of the controls (18.5 ±4.7 fmol/mg protein) were significantly different (P < 0.05, Mann-Whitney U-test). Mean (±SD) values of Kd for the patients (0.55 ± 0.34 nM) and for the controls (0.51 ± 0.12 nM) were not significantly different (P > 0.1, Mann-Whitney U-test). The results are discussed in terms of a serotonergic hypothesis of the aetiology of panic disorders. © 1990.