Journal article
A pharmacokinetic study of mianserin
KP Maguire, TR Norman, GD Burrows, BA Scoggins
European Journal of Clinical Pharmacology | SPRINGER HEIDELBERG | Published : 1982
DOI: 10.1007/BF00542048
Abstract
The kinetics of mianserin have been evaluated in eight healthy male volunteers following a single oral dose of 60 mg. Plasma and blood concentrations of mianserin were measured by gas chromatography-mass fragmentography. The peak blood concentration observed was 65 μg/l at 3 h following the dose. Mean kinetic parameters (and range) calculated from the blood concentrations were: (t1/2)abs 1.1 h (0.3-2.8), (t1/2)α 2.5 h (0.9-4.7), (t1/2)β 21 h (14-33), (Vd)β 27.5 l/kg (16.8-46.5) and Cloral 0.98 l/kg/h (0.47-1.75). Blood/plasma concentration ratios ranged from 0.50-0.74. © 1982 Springer-Verlag.