A KINETIC-ANALYSIS OF PLATELET MONOAMINE-OXIDASE ACTIVITY IN PATIENTS WITH PANIC ATTACKS
TR NORMAN, A ACEVEDO, IM MCINTYRE, FK JUDD, GD BURROWS
JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER SCIENCE BV | Published : 1988
A kinetic analysis of platelet monoamine oxidase (MAO) was performed in 22 patients with panic disorder and 14 normal controls, using tyramine as a substrate. Patients and controls did not differ significantly for either Km or Vmax, when same sex contrasts were carried out. The results do not support some studies that have shown elevated MAO activity in patients with panic attacks. The reasons for the discrepancies between previous studies and the present one are explored.