Journal article

PHARMACOKINETIC AND PHARMACODYNAMIC EFFECTS OF A SINGLE NOCTURNAL DOSE OF ALPRAZOLAM

TR NORMAN, GD BURROWS, IM MCINTYRE

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | RAPID SCIENCE PUBLISHERS | Published : 1990

Abstract

Six healthy volunteers participated in a study of the pharmacokinetic and psychomotor effects of a single dose of 2 mg of alprazolam compared to placebo when given at night. Alprazolam reached a maximum concentration in the plasma between 0.5 and 2.5 h after the dose. It was extensively distributed to the tissues as shown by the large apparent volume of distribution (1.42 l/kg) and slowly eliminated (t1/2 = 13.7 h). Significant impairment of choice reaction time occurred 1 and 11 h after the dose of alprazolam compared to placebo. Critical flicker fusion was also impaired after alprazolam but the difference from the placebo administration did not reach significance.

University of Melbourne Researchers