Onset of the effects of the 5-HT(1A) antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat

Abstract

5-HT(1A) receptor antagonists have recently been shown to accelerate the efects of some antidepressant drugs in clinical trials. In this study we investigate the effects of combining a full antagonist at the 5-HT(1A) receptor, WAY 100635 (0.2 mg/kg, SC) with the selective serotonin reuptake inhibitor (SSRI) paroxetine (5 mg/kg, IP) in the olfactory bulbectomized (OB) rat, an animal model of chronic (but not acute) antidepressant activity. Ambulation scores were measured in the open-field apparatus, following 3, 7, and 14 days of treatment. Further to the OB study, we simultaneously studied adaptive changes in 5-HT(1A) receptor function, utilizing alterations in the hypothermic response to th..