Journal article

Decision analysis of tamoxifen for the prevention of invasive breast cancer

VR Grann, V Sundararajan, JS Jacobson, W Whang, DF Heitjan, KH Antman, AI Neugut

CANCER JOURNAL | JONES AND BARTLETT PUBLISHERS | Published : 2000

Abstract

PURPOSE: The recent Breast Cancer Prevention Trial has shown that tamoxifen may prevent invasive breast cancer. We used a Markov model to estimate the long-term effects of chemoprevention with tamoxifen on survival, quality-adjusted survival, and health care costs. METHODS: We used a hypothetical cohort of women with breast-cancer risk similar to that of participants in the Breast Cancer Prevention Trial, and a computer-based decision analysis (Markov model and 500 Monte Carlo simulations) to model the outcomes of interest. Survival calculations were from Surveillance, Epidemiology, and End-Results (SEER) data; preference ratings from a time trade-off questionnaire administered to a group of..

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