Journal article

Probiotic therapy for pouchitis and its endoscopic findings

T Mimura, M Kaminishi, MA Kamm

Digestive Endoscopy | Published : 2002

Abstract

Restorative proctocolectomy with ileal pouch anal anastomosis has become the most frequently performed operation for ulcerative colitis. Patients having this operation, however, experience more short- and long-term complications than those with a permanent ileostomy. Pouchitis, acute non-specific inflammation within an ileal pouch, is one of the most common long-term complications after this procedure, and is specific to it. Although most pouchitis is amenable to simple antibiotic therapy including metronidazole and ciprofloxacin, 5-15% of patients suffer from refractory pouchitis, in which the acute inflammation either relapses frequently after the cessation of the antibiotics or does not r..

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