Journal article

The clinical significance of indomethacin-probenecid interaction.

PM Brooks, MA Bell, RD Sturrock, JP Famaey, WC Dick

Br J Clin Pharmacol | Published : 1974


1 The effect of the addition of probenecid to oral and rectal regimes of indomethacin was studied in three groups of rheumatoid arthritic patients. 2 The addition of probenecid increases plasma levels of indomethacin given both orally and rectally and significantly reduces the clinical parameters of joint inflammation. 3 The use of probenecid with indomethacin at night may be useful in reducing morning stiffness and pain. 4 Though indomethacin plasma levels are markedly raised during concurrent probenecid therapy remarkably few side effects were observed.

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