Journal article
Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
R Chowdhury, R Sekirnik, NC Brissett, T Krojer, CH Ho, SS Ng, IJ Clifton, W Ge, NJ Kershaw, GC Fox, JRC Muniz, M Vollmar, C Phillips, ES Pilka, KL Kavanagh, F von Delft, U Oppermann, MA McDonough, AJ Doherty, CJ Schofield
Nature | NATURE PUBLISHING GROUP | Published : 2014
DOI: 10.1038/nature13263
Abstract
2-Oxoglutarate (2OG)-dependent oxygenases have important roles in the regulation of gene expression via demethylation of N-methylated chromatin components and in the hydroxylation of transcription factors and splicing factor proteins. Recently, 2OG-dependent oxygenases that catalyse hydroxylation of transfer RNA and ribosomal proteins have been shown to be important in translation relating to cellular growth, TH17-cell differentiation and translational accuracy. The finding that ribosomal oxygenases (ROXs) occur in organisms ranging from prokaryotes to humans raises questions as to their structural and evolutionary relationships. In Escherichia coli, YcfD catalyses arginine hydroxylation in ..
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Awarded by Biotechnology and Biological Sciences Research Council
Funding Acknowledgements
We thank the Biotechnology and Biological Sciences Research Council, the Wellcome Trust, European Research Council, Medical Research Council, Oxford NIHR Biomedical Research Unit, Cancer Research UK, Arthritis Research UK, Bayer Healthcare, the Rosetree Foundation and the Slovenian Academy of Sciences and Arts (R. S.) for funding. We thank the scientists of beamlines X10SA (Swiss Light Source) and I02, I03, I04, I04-1 (Diamond Light Source) for assistance. The Structural Genomics Consortium is a registered charity (number 1097737) funded by Abbvie, Boehringer Ingelheim, the Canadian Institutes for Health Research, the Canadian Foundation for Innovation, Eli Lilly, Genome Canada, GlaxoSmithKline, the Ontario Ministry of Economic Development and Innovation, Janssen, Novartis Research Foundation, Pfizer, Takeda and the Wellcome Trust.