Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation

John S Scotti; Ivanhoe KH Leung; Wei Ge; Michael A Bentley; Jordi Paps; Holger B Kramer; Joongoo Lee; WeiShen Aik; Hwanho Choi; Steinar M Paulsen; Lesley AH Bowman; Nikita D Loik; Shoichiro Horita; Chia-hua Ho; Nadia J Kershaw; Christoph M Tang; Timothy DW Claridge; Gail M Preston; Michael A McDonough; Christopher J Schofield

Journal article

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation

John S Scotti, Ivanhoe KH Leung, Wei Ge, Michael A Bentley, Jordi Paps, Holger B Kramer, Joongoo Lee, WeiShen Aik, Hwanho Choi, Steinar M Paulsen, Lesley AH Bowman, Nikita D Loik, Shoichiro Horita, Chia-hua Ho, Nadia J Kershaw, Christoph M Tang, Timothy DW Claridge, Gail M Preston, Michael A McDonough, Christopher J Schofield

Proceedings of the National Academy of Sciences | NATL ACAD SCIENCES | Published : 2014

DOI: 10.1073/pnas.1409916111

University of Melbourne Researchers

Nadia Kershaw Author Medical Biology (W.E.H.I.)

Grants

Awarded by Biotechnology and Biological Sciences Research Council

Awarded by British Heart Foundation

Awarded by Engineering and Physical Sciences Research Council

Funding Acknowledgements

We thank the Diamond Macromolecular Crystallography beamline staff for technical support; Dr. Christoph Loenarz and Prof. Peter J. Ratcliffe for helpful discussion; and the Rhodes Trust (J.S.S.), the British Heart Foundation (I.K.H.L.), the Wellcome Trust, the European Research Council, the Japan Society for the Promotion of Science (S.H.), and the Biotechnology and Biological Sciences Research Council for financial support.