Journal article

AGE-RELATED-CHANGES IN EXTRAMEDULLARY HEMATOPOIESIS IN THE SPLEEN OF NORMAL AND PERTURBED OSTEOPETROTIC (OP/OP) MICE

SK NILSSON, I BERTONCELLO

EXPERIMENTAL HEMATOLOGY | CARDEN JENNINGS PUBL CO LTD | Published : 1994

Abstract

Occlusion of the marrow cavity by excessive bone formation in young osteopetrotic (op/op) mice results in a significant reduction in the space available for hematopoiesis. At this time, splenomegaly is evident, and the spleen is a site of significant extramedullary hematopoiesis. In vitro clonal assays of spleen cell suspensions in young op/op mice demonstrated a 22-fold elevation in the content of high proliferative potential colony-forming cells (HPP-CFC) (4 weeks of age) and a 14-fold elevation in the content of committed progenitors responsive to colony-stimulating factor-1 (CSF-1) (6 weeks of age). Flow-cytometric analysis also demonstrated a shift in the myeloid:lymphoid cell ratio in ..

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