Journal article

GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IS NOT RESPONSIBLE FOR THE CORRECTION OF HEMATOPOIETIC DEFICIENCIES IN THE MATURING OP/OP MOUSE

SK NILSSON, GJ LIESCHKE, CC GARCIAWIJNEN, B WILLIAMS, D TZELEPIS, G HODGSON, D GRAIL, AR DUNN, I BERTONCELLO

BLOOD | W B SAUNDERS CO | Published : 1995

Abstract

Osteopetrotic (op/op) mice are characterized by an autosomal recessive inactivating mutation resulting in the absence of biologically active colony-stimulating factor-1 (CSF-1). Consequently, young op/op mice have a severe deficiency of macrophages and osteoclasts resulting in excessive bone formation, occlusion of the marrow cavity, and reduced marrow hematopoietic activity. Recently, we showed that the osteopetrosis and hematopoietic deficiencies evident in young op/op mice are not permanent but are progressively corrected with age. There are increases in osteoclast activity; bone resorption; femoral marrow space; and marrow hematopoietic activity, cellularity, and macrophage content. In t..

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University of Melbourne Researchers