Journal article

THE DEVELOPMENT AND ESTABLISHMENT OF HEMATOPOIESIS IN FETAL AND NEWBORN OSTEOPETROTIC (OP/OP) MICE

SK NILSSON, I BERTONCELLO

DEVELOPMENTAL BIOLOGY | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS | Published : 1994

Abstract

Previous studies of young CSF-1-less osteopetrotic (op/op) mice demonstrate a severe deficiency of both macrophages and osteoclasts, resulting in excessive bone formation, occlusion of the marrow cavity, and reduced hemopoietic activity. The accompanying splenomegaly and prolonged splenic hemopoiesis observed in these mice suggests that osteopetrosis may perturb the normal progression of fetal hemopoietic development and obstruct the seeding of hemopoietic precursors into the bone marrow. This study demonstrates that the absence of CSF-1 does not affect the progression of hemopoietic development in fetal op/op mice until after colonization of the bone marrow. Significant deficiencies in marr..

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University of Melbourne Researchers