Journal article

Characterization of pancreatic islet cell infiltrates in NOD mice: effect of cell transfer and transgene expression.

LA O'Reilly, PR Hutchings, PR Crocker, E Simpson, T Lund, D Kioussis, F Takei, J Baird, A Cooke

Eur J Immunol | Published : 1991

Abstract

Insulin-dependent diabetes mellitus can be transferred into young irradiated non-obese diabetic (NOD) mice by spleen cells from a diabetic NOD donor. T cells (both L3T4+ and Ly-2+) enter the pancreas 2 weeks following transfer. They are present initially at peri-islet locations but progressively infiltrate the islet with accompanying beta cell destruction. The infiltrate is heterogeneous with respect to V beta usage. Inflammatory macrophages (Mac-1+, F4/80+) can be detected at peri-islet locations at 1 week after transfer and continue to be recruited during the disease process. Their presence at the initiation of disease suggests that their primary function may be autoantigen presentation. I..

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