Molecular imaging of the dopaminergic system and its association with human cognitive function.
Vanessa L Cropley, Masahiro Fujita, Robert B Innis, Pradeep J Nathan
Biological Psychiatry | Published : 2006
Molecular imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) has recently been used to examine dopamine (DA) function and its relationship with cognition in human subjects. This article will review PET and SPECT studies that have explored the relationship between cognitive processes and components of the DA system (pre-, intra-, and postsynaptic) in healthy and patient populations such as Parkinson's disease (PD), schizophrenia, Huntington's disease, and aging. It is demonstrated that DA activity modulates a range of frontal executive-type cognitive processes such as working memory, attentional functioning, and sequential organization, and ..View full abstract