Journal article

SYNTHESIS AND RECEPTOR-BINDING ACTIVITY OF ELEPHANT BETA-ENDORPHIN, A BETA-ENDORPHIN HOMOLOG WITH HIGHLY POTENT ANALGESIC ACTIVITY

HC CHENG, D YAMASHIRO

INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH | MUNKSGAARD INT PUBL LTD | Published : 1991

Abstract

Elephant beta-endorphin and its analog, elephant beta-endorphin(6-31) were synthesized by standard solid phase method. Receptor binding activity showed that elephant beta-endorphin was five to six times more potent than human beta-endorphin in its ability to bind to opiate receptors on rat brain membrane. In a previous study (Wong, C.-L., Wai, M.-K., Cheng, H.-C., Chung, D. & Yamashiro, D (1990) Clinical and Experimental Pharmacology and Physiology 16, 33-37), tail flick test for intracerebroventricularly administered beta-endorphin showed that the antinociceptive potency of elephant beta-endorphin was seven to eight times higher than that of human beta-endorphin in mice. Results from both s..

View full abstract