Trabecular Bone Score in Men and Women with Impaired Fasting Glucose and Diabetes

Kara L Holloway; Lelia LF De Abreu; Didier Hans; Mark A Kotowicz; Muhammad A Sajjad; Natalie K Hyde; Julie A Pasco

Journal article

Trabecular Bone Score in Men and Women with Impaired Fasting Glucose and Diabetes

Kara L Holloway, Lelia LF De Abreu, Didier Hans, Mark A Kotowicz, Muhammad A Sajjad, Natalie K Hyde, Julie A Pasco

CALCIFIED TISSUE INTERNATIONAL | SPRINGER | Published : 2018

DOI: 10.1007/s00223-017-0330-z

Abstract

Diabetes is associated with increased skeletal fragility, despite higher bone mineral density (BMD). Alternative measures are necessary to more accurately determine fracture risk in individuals with diabetes. Therefore, we aimed to describe the relationship between trabecular bone score (TBS) and normoglycaemia, impaired fasting glucose (IFG) and diabetes and determine whether TBS-adjusted FRAX (Aus) score differed between these groups. This study included 555 men (68.7 ± 12.2 years) and 514 women (62.0 ± 12.0 years), enrolled in the observational Geelong Osteoporosis Study. IFG was considered as fasting plasma glucose (FPG) ≥ 5.5 mmol/L and diabetes as FPG ≥ 7.0 mmol/L, with the use of anti..

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University of Melbourne Researchers

Mark Kotowicz Author

Julie Pasco Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Funding Acknowledgements

Study was supported by the National Health and Medical Research Council (NHMRC) of Australia (251638, 299831, 628582), the Geelong Regional Medical Foundation, Arthritis Foundation of Australia and Perpetual Trustees. NKH is supported by an Australian Postgraduate Award. KLH is supported by an Alfred Deakin Postdoctoral Research Fellowship. LLFA and MAS are supported by Deakin Postgraduate Scholarships.