CISH and Susceptibility to Infectious Diseases
Chiea C Khor, Fredrik O Vannberg, Stephen J Chapman, Haiyan Guo, Sunny H Wong, Andrew J Walley, Damjan Vukcevic, Anna Rautanen, Tara C Mills, Kwok-Chiu Chang, Kai-Man Kam, Amelia C Crampin, Bagrey Ngwira, Chi-Chiu Leung, Cheuk-Ming Tam, Chiu-Yeung Chan, Joseph JY Sung, Wing-Wai Yew, Kai-Yee Toh, Stacey KH Tay Show all
NEW ENGLAND JOURNAL OF MEDICINE | MASSACHUSETTS MEDICAL SOC | Published : 2010
BACKGROUND: The interleukin-2-mediated immune response is critical for host defense against infectious pathogens. Cytokine-inducible SRC homology 2 (SH2) domain protein (CISH), a suppressor of cytokine signaling, controls interleukin-2 signaling. METHODS: Using a case-control design, we tested for an association between CISH polymorphisms and susceptibility to major infectious diseases (bacteremia, tuberculosis, and severe malaria) in blood samples from 8402 persons in Gambia, Hong Kong, Kenya, Malawi, and Vietnam. We had previously tested 20 other immune-related genes in one or more of these sample collections. RESULTS: We observed associations between variant alleles of multiple CISH polym..View full abstract
Awarded by Medical Research Council
Supported by grants (to Drs. Khor, Goh, and Hill) and clinical research fellowships (to Drs. Chapman, Williams, Scott, and Berkley) from the Wellcome Trust and the Agency for Science, Technology and Research, Singapore; and by the Wellcome Trust Kenya Major Overseas Programme.