Journal article

Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept

ML Hamshere, EK Green, IR Jones, L Jones, V Moskvina, G Kirov, D Grozeva, I Nikolov, D Vukcevic, S Caesar, K Gordon-Smith, C Fraser, E Russell, G Breen, D St Clair, DA Collier, AH Young, IN Ferrier, A Farmer, P McGuffin Show all

The British Journal of Psychiatry | CAMBRIDGE UNIV PRESS | Published : 2009

Abstract

BACKGROUND: Psychiatric phenotypes are currently defined according to sets of descriptive criteria. Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological-genetic research. AIMS: To use genome-wide genetic association data to explore the relative genetic utility of seven different descriptive operational diagnostic categories relevant to bipolar illness within a large UK case-control bipolar disorder sample. METHOD: We analysed our previously published Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder genome-wide association data-set, ..

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University of Melbourne Researchers