Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept
ML Hamshere, EK Green, IR Jones, L Jones, V Moskvina, G Kirov, D Grozeva, I Nikolov, D Vukcevic, S Caesar, K Gordon-Smith, C Fraser, E Russell, G Breen, D St Clair, DA Collier, AH Young, IN Ferrier, A Farmer, P McGuffin Show all
The British Journal of Psychiatry | CAMBRIDGE UNIV PRESS | Published : 2009
BACKGROUND: Psychiatric phenotypes are currently defined according to sets of descriptive criteria. Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological-genetic research. AIMS: To use genome-wide genetic association data to explore the relative genetic utility of seven different descriptive operational diagnostic categories relevant to bipolar illness within a large UK case-control bipolar disorder sample. METHOD: We analysed our previously published Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder genome-wide association data-set, ..View full abstract
Awarded by Wellcome Trust
Awarded by Medical Research Council
Funding for recruitment and phenotype assessment has been provided by the Wellcome Trust (060620) and the Medical Research Council (G0000647). The genotype analyses were funded by the Wellcome Trust and undertaken within the context of the Wellcome Trust Case Control Consortium (WTCCC).