Journal article
Imaging lenticular autofluorescence in older subjects
J Charng, R Tan, CD Luu, S Sadigh, D Stambolian, RH Guymer, SG Jacobson, AV Cideciyan
Investigative Ophthalmology and Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2017
Open access
Abstract
Purpose: To evaluate whether a practical method of imaging lenticular autofluorescence (AF) can provide an individualized measure correlated with age-related lens yellowing in older subjects undergoing tests involving shorter wavelength lights. Methods: Lenticular AF was imaged with 488-nm excitation using a confocal scanning laser ophthalmoscope (cSLO) routinely used for retinal AF imaging. There were 75 older subjects (ages 47-87) at two sites; a small cohort of younger subjects served as controls. At one site, the cSLO was equipped with an internal reference to allow quantitative AF measurements; at the other site, reduced-illuminance AF imaging (RAFI) was used. In a subset of subjects, l..
View full abstractGrants
Awarded by Macula Vision Research Foundation
Funding Acknowledgements
Supported by grants from the Pennsylvania Department of Health (Philadelphia, PA, USA), Macula Vision Research Foundation (Philadelphia, PA, USA), Beckman Initiative for Macular Research (Irvine, CA, USA), Foundation Fighting Blindness (Columbia, MD, USA), Research to Prevent Blindness (New York, NY, USA), National Eye Institute (EY001583; Bethesda, MD, USA), Macular Disease Foundation Australia (Melbourne, VIC, Australia), The National Health and Medical Research Council (NHMRC) Australia Project Grant (#1084081; Canberra, ACT, Australia), The NHMRC Principal Research Fellowship (Canberra, ACT, Australia). The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government.