Maternal stress does not exacerbate long-term bone deficits in female rats born growth restricted, with differential effects on offspring bone health
Kristina Anevska, Jean N Cheong, John D Wark, Mary E Wlodek, Tania Romano
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2018
Females born growth restricted have poor adult bone health. Stress exposure during pregnancy increases risk of pregnancy complications. We determined whether maternal stress exposure in growth-restricted females exacerbates long-term maternal and offspring bone phenotypes. On gestational day 18, bilateral uterine vessel ligation (restricted) or sham (control) surgery was performed on Wistar-Kyoto rats. At 4 mo, control and restricted females were mated and allocated to unstressed or stressed pregnancies. Stressed pregnancies had physiological measurements performed; unstressed females were not handled. After birth, mothers were aged to 13 mo. Second-generation (F2) offspring generated four e..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was funded by the National Health and Medical Research Council of Australia (Grant 1025426) awarded to M. E. Wlodek. J. N. Cheong received support from an Australian Postgraduate Award scholarship from The University of Melbourne. K. Anevska received support by an Australian Government Research Training Program Scholarship.