Journal article
Tumour mutation status and sites of metastasis in patients with cutaneous melanoma
NR Adler, R Wolfe, JW Kelly, A Haydon, GA McArthur, CA McLean, VJ Mar
British Journal of Cancer | NATURE PUBLISHING GROUP | Published : 2017
DOI: 10.1038/bjc.2017.254
Abstract
Background:Cutaneous melanoma can metastasise haematogenously and/or lymphogenously to form satellite/in-transit, lymph node or distant metastasis. This study aimed to determine if BRAF and NRAS mutant and wild-type tumours differ in their site of first tumour metastasis and anatomical metastatic pathway.Methods:Prospective cohort of patients with a histologically confirmed primary cutaneous melanoma at three tertiary referral centres in Melbourne, Australia from 2010 to 2015. Multinomial regression determined clinical, histological and mutational factors associated with the site of first metastasis and metastatic pathway.Results:Of 1048 patients, 306 (29%) developed metastasis over a median..
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Funding Acknowledgements
We would like to thank Ms Sonia Louise Mailer for her work as the MMP database manager. NRA is supported by the Australian Postgraduate Award; this research project was supported by the Victorian Government through the Victorian Cancer Agency Translational Research Program; GAM is supported by the NHMRC and The Lorenzo Galli Chair in melanoma and Skin Cancer from the University of Melbourne.