Journal article
Extensive genetic differentiation between homomorphic sex chromosomes in the mosquito vector, Aedes aegypti
A Fontaine, I Filipović, T Fansiri, AA Hoffmann, C Cheng, M Kirkpatrick, G Rašić, L Lambrechts
Genome Biology and Evolution | OXFORD UNIV PRESS | Published : 2017
DOI: 10.1093/gbe/evx171
Abstract
Mechanisms and evolutionary dynamics of sex-determination systems are of particular interest in insect vectors of human pathogens like mosquitoes because novel control strategies aim to convert pathogen-transmitting females into nonbiting males, or rely on accurate sexing for the release of sterile males. In Aedes aegypti, the main vector of dengue and Zika viruses, sex determination is governed by a dominant male-determining locus, previously thought to reside within a small, nonrecom-bining, sex-determining region (SDR) of an otherwise homomorphic sex chromosome. Here, we provide evidence that sex chromosomes in Ae.aegyptiare genetically differentiated between malesand females over a regio..
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Awarded by National Institutes of Health
Funding Acknowledgements
We thank Alongkot Ponlawat, Jason Richardson, three anonymous reviewers and the Lambrechts lab members for their insights. We are grateful to Eric Deveaud, Nicolas Joly, Olivia Doppelt-Azeroual and Veronique Legrand for assistance with computational analysis, and to the Nectar Research Cloud for computational resources. The opinions or assertions contained herein are the private views of the authors and are not to be construed as reflecting the official views of the United States Army, Royal Thai Army, or the United States Department of Defense. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. This work was supported by Agence Nationale de la Recherche grant ANR-09-RPDOC-007-01, the French Government's Investissement d'Avenir program Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases grant ANR-10-LABX-62-IBEID, the City of Paris Emergence(s) program in Biomedical Research, the European Union's Horizon 2020 research and innovation programme under ZikaPLAN grant agreement No 734584, Delegation Generale pour l'Armement grant No PDH-2-NRBC-4-B1-405, National Institutes of Health grant R01-GM116853, Swiss National Science Foundation grant CRSII3-147625, The University of Melbourne Early Career Researcher grant 501152, Centre National de la Recherche Scientifique Visiting Researcher grant 1451452, and National Health and Medical Research Council program and fellowship grants.