Journal article

Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells

Leah Fitzsimmons, Andrew J Boyce, Wenbin Wei, Catherine Chang, Deborah Croom-Carter, Rosemary J Tierney, Marco J Herold, Andrew I Bell, Andreas Strasser, Gemma L Kelly, Martin Rowe

Cell Death and Differentiation | NATURE PUBLISHING GROUP | Published : 2018


Awarded by Kay Kendall Leukaemia Fund

Awarded by Cancer Research UK

Awarded by Cancer Council Victoria

Awarded by National Health and Medical Research Council

Awarded by Leukaemia and Lymphoma Society

Awarded by Grants-in-Aid for Scientific Research

Funding Acknowledgements

We thank Profs Kenzo Takada and Teru Kanda for provision of the Akata-BL cell line, the pEKS10 plasmid and recombinant Akata-GFP2-producing Akata-BL cells; Tracey Haigh and Dr. Graham Taylor for cloning EBNA1 into the FTrex-UTG lentivirus; Dr. Toru Okamoto for generating the BIMS variant expressing lentiviruses and Giovanni Sicilano, Carmen Gatt and Hannah Johnson for mouse husbandry. We are also grateful to Prof. Alan Rickinson for critical reading of the manuscript. This work was supported by funding from: the Kay Kendall Leukaemia Fund Fellowship KKL331 awarded to GLK; Cancer Research UK, Programme Grant C5575/A15032 awarded to MR; Cancer Council Victoria, grant-in-aid no. 1086157 awarded to GLK; the National Health and Medical Research Council, Project Grant No. 1086291 awarded to GLK, Program Grant No. 101671 awarded to AS, Fellowship No. 1020363 awarded to AS; the Leukaemia and Lymphoma Society, Grant No. 7001-13 awarded to AS; and the estate of Anthony (Toni) Redstone OAM.