Rilmenidine promotes MTOR-independent autophagy in the mutant SOD1 mouse model of amyotrophic lateral sclerosis without slowing disease progression

Nirma D Perera; Rebecca K Sheean; Chew L Lau; Yea Seul Shin; Philip M Beart; Malcolm K Horne; Bradley J Turner

Journal article

Rilmenidine promotes MTOR-independent autophagy in the mutant SOD1 mouse model of amyotrophic lateral sclerosis without slowing disease progression

Nirma D Perera, Rebecca K Sheean, Chew L Lau, Yea Seul Shin, Philip M Beart, Malcolm K Horne, Bradley J Turner

Autophagy | TAYLOR & FRANCIS INC | Published : 2018

DOI: 10.1080/15548627.2017.1385674

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University of Melbourne Researchers

Linda Lau Author Florey Department of Neuroscience and Mental Health

Nirma Perera Author Florey Department of Neuroscience and Mental Health

Bradley Turner Author Florey Department of Neuroscience and Mental Health

Philip Beart Author Florey Department of Neuroscience and Mental Health

Malcolm Horne Author Florey Department of Neuroscience and Mental Health

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Grants

Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

This work was supported by grants from the Australian National Health and Medical Research Council (Project Grants 1104299 and 1104295), Stafford Fox Medical Research Foundation, MND Research Institute of Australia (Susie Harris Memorial Fund and Zo-ee MND Research Grants), Bethlehem Griffiths Research Foundation, Cavalier Courage MND Research Grant, Melbourne Support Grant Research Scheme and Inner Wheel Club of Pakenham. The Florey Institute of Neuroscience and Mental Health acknowledge the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. N.D.P. is supported by an Australian Postgraduate Award Scholarship.