Journal article

Association between mammographic density and tumor marker-defined breast cancer subtypes: a case-control study

Jinyoung Shin, Jeong Eon Lee, Hyeon Young Ko, Linh Nguyen Tuong, Seok Jin Nam, John Llewelyn Hopper, Yun-Mi Song

EUROPEAN JOURNAL OF CANCER PREVENTION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018

Abstract

High mammographic density (MD) is the most important risk factor for breast cancer. This study aimed to clarify the relationship between MD and breast cancer subtypes defined by tumor markers. We enrolled 642 women with breast cancer (69% premenopausal) and 1241 controls matched for age and menopausal status. Absolute mammographic dense area (ADA), percent mammographic dense area (PDA), and nondense area were assessed using a computer-assisted thresholding technique. We classified breast cancer cases into four subtypes using information on tumor marker expression such as estrogen receptor (ER), progesterone receptor (PR), and Cerb2 receptor (HER2); luminal A (ER+ and/or PR+, HER2-), luminal ..

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Grants

Awarded by Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT, and future Planning


Awarded by Ministry of Health & Welfare, Republic of Korea


Funding Acknowledgements

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and future Planning (2011-0013545 and 2014R1A2A2A01002705) and by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C3418).