A systemic view of Alzheimer disease - insights from amyloid-beta metabolism beyond the brain
Jun Wang, Ben J Gu, Colin L Masters, Yan-Jiang Wang
NATURE REVIEWS NEUROLOGY | NATURE PUBLISHING GROUP | Published : 2017
Alzheimer disease (AD) is the most common type of dementia, and is currently incurable; existing treatments for AD produce only a modest amelioration of symptoms. Research into this disease has conventionally focused on the CNS. However, several peripheral and systemic abnormalities are now understood to be linked to AD, and our understanding of how these alterations contribute to AD is becoming more clearly defined. This Review focuses on amyloid-β (Aβ), a major hallmark of AD. We review emerging findings of associations between systemic abnormalities and Aβ metabolism, and describe how these associations might interact with or reflect on the central pathways of Aβ production and clearance...View full abstract
Awarded by National Natural Science Foundation of China
Awarded by Chinese Ministry of Science and Technology
The authors' research work is supported by the National Natural Science Foundation of China (grants 81471296 and 81625007 to Y.-J.W., and grant 81600949 to J.W.), and the Chinese Ministry of Science and Technology (grant 2016YFC1306401 to Y.-J.W.). The authors thank Dr J. Pina-Crespo and Dr H. Xu at Sanford Burnham Prebys Medical Discovery Institute, USA, for critical reading of the paper.