Journal article

Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global beta-Amyloid Burden

Rachel F Buckley, Bernard Hanseeuw, Aaron P Schultz, Patrizia Vannini, Sarah L Aghjayan, Michael J Properzi, Jonathan D Jackson, Elizabeth C Mormino, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Rebecca E Amariglio

JAMA NEUROLOGY | AMER MEDICAL ASSOC | Published : 2017

Abstract

Importance: The ability to explore associations between reports of subjective cognitive decline (SCD) and biomarkers of early Alzheimer disease (AD) pathophysiologic processes (accumulation of neocortical β-amyloid [Aβ] and tau) provides an important opportunity to understand the basis of SCD and AD risk. Objective: To examine associations between SCD and global Aβ and tau burdens in regions of interest in clinically healthy older adults. Design, Setting, and Participants: This imaging substudy of the Harvard Aging Brain Study included 133 clinically healthy older participants (Clinical Dementia Rating Scale global scores of 0) participating in the Harvard Aging Brain Study who underwent cro..

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Grants

Awarded by Center for Functional Neuroimaging Technologies


Awarded by Australian National Health and Medical Research Council


Awarded by Belgian National Science Foundation


Awarded by National Institutes of Health (NIH)


Awarded by NIH


Awarded by Belgian Foundation for Alzheimer Research


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

This study was supported by the Dementia Research Fellowship APP1105576 from the Australian National Health and Medical Research Council (Dr Buckley); grants P01AG036694 (Drs Sperling and Johnson),P50 AG005134 (Drs Sperling and Johnson),R01 AG046396 (Dr Johnson), and K24 AG035007 (Dr Sperling) from the National Institutes of Health (NIH); grant SPD28094292 from the Belgian National Science Foundation; grant P16008 from the Belgian Foundation for Alzheimer Research (Dr Hanseeuw); and grant K23 AG044431 from the NIH (Dr Amariglio). This research was performed in part at the Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital, using Biotechnology Resource Grant P41EB015896 from the Center for Functional Neuroimaging Technologies, the National Institute of Biomedical Imaging and Bioengineering, NIH.This work also involved the use of instrumentation supported by grants S10RR021110, S10RR023401, and S10RR023043 from the NIH Shared Instrumentation Grant Program and/or High-End Instrumentation Grant Program.