Journal article

INTERACTION OF FUROSEMIDE WITH SERUM THYROXINE-BINDING SITES - INVIVO AND INVITRO STUDIES AND COMPARISON WITH OTHER INHIBITORS

JR STOCKIGT, CF LIM, JW BARLOW, KN WYNNE, VS MOHR, DJ TOPLISS, PS HAMBLIN, J SABTO

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | ENDOCRINE SOC | Published : 1985

Abstract

The diuretic furosemide inhibits serum protein binding of T4 in equilibrium dialysis, dextran-charcoal, and competitive ligand binding separation systems and displaces [125I]T4 from isolated preparations of T4-binding globulin (TBG), prealbumin, and albumin. Equilibrium dialysis studies of undiluted normal serum showed that about 10 micrograms/ml furosemide increased the free T4 and free T3 fractions. Displacement occurred at lower drug concentrations in sera with subnormal albumin and TBG levels. Binding of [14C]furosemide to TBG was inhibited by unlabeled T4, suggesting that furosemide and T4 share a common binding site. A single oral dose of 500 mg furosemide given to five patients mainta..

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