Journal article

PRACTICAL MANAGEMENT OF DIABETIC-KETOACIDOSIS AND HYPEROSMOLAR COMA

PS HAMBLIN, DJ TOPLISS, JR STOCKIGT

Australian and New Zealand Journal of Medicine | ADIS PRESS AUSTRALASIA P/L | Published : 1990

Abstract

In diabetic ketoacidosis (DKA) and particularly in hyperosmolar coma, rapid normalisation of the measured extracellular fluid abnormalities cannot be equated with optimal management. In both disorders there are complex imbalances between extra- and intracellular compartments that are best corrected in a series of rational steps, based on an understanding of pathophysiology. Fluid administration in DKA can generally be divided into three successive phases: (i) a short period of rapid isotonic saline infusion, (ii) slower infusion of isotonic saline with potassium chloride, and (iii) glucose-potassium infusion until oral food intake is well established. In severe cases, there is a definite pla..

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University of Melbourne Researchers