Journal article
Post-stroke inhibition of induced NADPH Oxidase type 4 prevents oxidative stress and neurodegeneration
C Kleinschnitz, H Grund, K Wingler, ME Armitage, E Jones, M Mittal, D Barit, T Schwarz, C Geis, P Kraft, K Barthel, MK Schuhmann, AM Herrmann, SG Meuth, G Stoll, S Meurer, A Schrewe, L Becker, V Gailus-Durner, H Fuchs Show all
Plos Biology | PUBLIC LIBRARY SCIENCE | Published : 2010
Abstract
Ischemic stroke is the second leading cause of death worldwide. Only one moderately effective therapy exists, albeit with contraindications that exclude 90% of the patients. This medical need contrasts with a high failure rate of more than 1,000 pre-clinical drug candidates for stroke therapies. Thus, there is a need for translatable mechanisms of neuroprotection and more rigid thresholds of relevance in pre-clinical stroke models. One such candidate mechanism is oxidative stress. However, antioxidant approaches have failed in clinical trials, and the significant sources of oxidative stress in stroke are unknown. We here identify NADPH oxidase type 4 (NOX4) as a major source of oxidative str..
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Awarded by European Commission
Funding Acknowledgements
This work was supported by the NHMRC, Australia, the Deutsche Forschungsgemeinschaft (DFG), Germany (to HHHWS and CK), and by the Bundesministerium fur Bildung und Forschung within the framework of the NGFN-Plus and the European Commission (EUMODIC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.