The Function of the Golgi Ribbon Structure - An Enduring Mystery Unfolds!
Prajakta Gosavi, Paul A Gleeson
BIOESSAYS | WILEY | Published : 2017
The Golgi apparatus in vertebrate cells consists of individual Golgi stacks fused together in a continuous ribbon structure. The ribbon structure per se is not required to mediate the classical functions of this organelle and the relevance of the "ribbon" structure has been a mystery since first identified ultrastructurally in the 1950s. Recent advances recognize a role for the Golgi apparatus in a range of cellular processes, some mediated by signaling networks which are regulated at the Golgi. Here we review the cellular processes and signaling events regulated by the Golgi apparatus and, in particular, explore an emerging theme that the ribbon structure of the Golgi contributes directly t..View full abstract
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Awarded by Australian Research Council
The authors gratefully acknowledge Dr. Paul McMillan and the Biological Optical Microscopy Platform (BOMP), University of Melbourne, for assistance with super-resolution microscopy, and Christian Makhoul for helpful suggestions. This work was supported by funding from Australian Research Council (DP160102394).