Journal article
A mathematical model of antibody-dependent cellular cytotoxicity (ADCC)
F Hoffman, D Gavaghan, J Osborne, IP Barrett, T You, H Ghadially, R Sainson, RW Wilkinson, HM Byrne
Journal of Theoretical Biology | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2018
Open access
Abstract
Immunotherapies exploit the immune system to target and kill cancer cells, while sparing healthy tissue. Antibody therapies, an important class of immunotherapies, involve the binding to specific antigens on the surface of the tumour cells of antibodies that activate natural killer (NK) cells to kill the tumour cells. Preclinical assessment of molecules that may cause antibody-dependent cellular cytotoxicity (ADCC) involves co-culturing cancer cells, NK cells and antibody in vitro for several hours and measuring subsequent levels of tumour cell lysis. Here we develop a mathematical model of such an in vitro ADCC assay, formulated as a system of time-dependent ordinary differential equations ..
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Funding Acknowledgements
FH gratefully acknowledges funding from the ESPRC, MRC, Astrazeneca and Medimmune. We thank Professor Kevin Burrage (Queensland University of Technology), Dr Mark Penney (Medimmune, Cambridge), Professor Mark Coles (University of Leeds) and Dr Alex Phipps (Roche, UK) for helpful discussions.