Journal article

CHARACTERIZATION OF OVINE GROWTH-HORMONE (OGH) AND OVINE PLACENTAL-LACTOGEN (OPL) BINDING TO FETAL AND ADULT HEPATIC TISSUE IN SHEEP - EVIDENCE THAT OGH AND OPL INTERACT WITH A COMMON RECEPTOR

BH BREIER, B FUNK, A SURUS, GR AMBLER, CA WELLS, MJ WATERS, PD GLUCKMAN

ENDOCRINOLOGY | ENDOCRINE SOC | Published : 1994

Abstract

The GH receptor (GHR) plays a key role in postnatal growth regulation. Although plasma concentrations of GH are high during fetal life, its role during fetal development is not well understood. Recent data suggest that GHR are present in fetal hepatic tissue as early as 51 days gestation. However, the levels of GHR expression are markedly lower in fetal hepatic tissue compared to postnatal values, and there are conflicting data suggesting that ovine placental lactogen (oPL) and oGH share a common receptor. Given the uncertainty about whether oPL acts via the oGHR or a distinct receptor, we performed ligand binding and affinity cross-linking studies on hepatic microsomal membranes from adult ..

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University of Melbourne Researchers