TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain

S Carpenter; T Carlson; J Dellacasagrande; A Garcia; S Gibbons; P Hertzog; A Lyons; LL Lin; M Lynch; T Monie; C Murphy; KJ Seidl; C Wells; A Dunne; LAJ O'Neill

Journal article

TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain

S Carpenter, T Carlson, J Dellacasagrande, A Garcia, S Gibbons, P Hertzog, A Lyons, LL Lin, M Lynch, T Monie, C Murphy, KJ Seidl, C Wells, A Dunne, LAJ O'Neill

Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2009

DOI: 10.4049/jimmunol.0901518

Abstract

TLR4 is the primary sensor of LPS. In this study, we describe for the first time TLR4 interactor with leucine-rich repeats (TRIL), which is a novel component of the TLR4 complex. TRIL is expressed in a number of tissues, most prominently in the brain but also in the spinal cord, lung, kidney, and ovary. TRIL is composed of a signal sequence, 13 leucine-rich repeats, a fibronectin domain, and a single transmembrane spanning region. TRIL is induced by LPS in the human astrocytoma cell line U373, in murine brain following i.p. injection, and in human PBMC. Endogenous TRIL interacts with TLR4 and this interaction is greatly enhanced following LPS stimulation. TRIL also interacts with the TLR4 li..

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