Evidence-based adjuvant treatment of resectable pancreatic adenocarcinoma

Abstract

Pancreatic adenocarcinoma (PAC) remains one of the most lethal cancers. The overall 5-year survival rate (all stages) remains <5%. Most people present with advanced disease and even the minority who present with resectable disease still, predominantly, die of recurrent metastatic cancer. Adjuvant treatment after surgical resection has been proposed as a method of increasing the cure rate of patients with PAC, but despite developments in new systemic and radiation treatment techniques, the optimal adjuvant therapy, according to the available evidence, is yet to be clearly defined. Adjuvant systemic chemotherapy, radiotherapy or chemoradiotherapy have all been investigated as strategies to imp..