An Autoradiographic Study of the Developing Parietal Cell Population In Neonatal Pigs

Abstract

Abstract. Autoradiographic labelling using tritiated thymidine ([ 3 H]TdR) was used to examine the pattern of development of gastric parietal cells in newborn pigs. Specific objectives were to establish sites in the gland where cells with a characteristic parietal cell morphology first appear, the extent of their migration or displacement, and the kinetics of any development and migration that occurs. Five newly‐born littermate piglets were given a virtually continuous label of [ 3 H]TdR over 24 hr, sacrificed at 1, 3, 5, 7 and 10 days thereafter, and samples of the gastric mucosa taken. the percentage of labelled parietal cells as a function of position in the oxyntic gland was measured for..