A family study of panic disorder: Reanalysis using a regressive logistic model that incorporates a sibship environment

Abstract

Previous analysis of affection status in parents and siblings of 117 probands with panic disorder by a log‐linear model for binary pedigree data found a common concordance across biological first‐degree relatives and no spouse association [Hopper JL, Judd FK, Derrick PL, Burrows GD: Genet Epidemiol 4:33–41, 1987]. In this paper the data were reanalyzed using a regressive logistic model that modelled both vertical transmission and a shared sibship environment. Ascertainment correction was made by a) an “ascertainment assumption‐free” procedure, following Ewens and Shute [Theor Pop Biol 30:388–412, 1986] and compared with b) complete ascertainment and c) single ascertainment. Under every schem..