Gastrin processing and secretion in patients with end-stage renal failure

Abstract

Gastrin circulates at higher than normal concentrations in patients with end-stage renal failure (ESRF). However, it remains unclear which forms of gastrin are elevated and whether there is also an alteration in the secretory profile after stimulation. In the present study all processed and partially processed forms of circulating gastrin were measured in plasma before and after meal stimulation in ESRF patients and control subjects. Since Helicobacter pylori (HP) infection affects gastrin secretion, HP status was determined. Fasting gastrin-amide (36 ± 8 pmol/L), gastrin-Gly (55 ± 16 pmol/L), and total gastrin (218 ± 32 pmol/L) measured in ESRF/HP-patients were all significantly greater tha..