Journal article

Runx3 regulates integrin alpha(E)/CD103 and CD4 expression during development of CD4(-)/CD8( ) T cells

B Grueter, M Petter, T Egawa, K Laule-Kilian, CJ Aldrian, A Wuerch, Y Ludwig, H Fukuyama, H Wardemann, R Waldschuetz, T Moroy, I Taniuchi, V Steimle, DR Littman, M Ehlers

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2005

Abstract

During thymic T cell development, immature CD4+CD8+ double-positive (DP) thymocytes develop either into CD4+CD8- Th cells or CD4-CD8+ CTLs. Differentially expressed primary factors inducing the fate of these cell types are still poorly described. The transcription factor Runx3/AML-2 Runx, runt [corrected] dominant factor; AML, acute myeloid leukemia is expressed specifically during the development of CD8 single-positive (SP) thymocytes, where it silences CD4 expression. Deletion of murine Runx3 results in a reduction of CD8 SP T cells and concomitant accumulation of CD4+CD8+ T cells, which cannot down-regulate CD4 expression in the thymus and periphery. In this study we have investigated the..

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University of Melbourne Researchers