Journal article

Epstein-Barr virus LMP1 blocks p(16INK4a)-RB pathway by promoting nuclear export of E2F4/5

N Ohtani, P Brennan, S Gaubatz, E Sanij, P Hertzog, E Wolvetang, J Ghysdael, M Rowe, E Hara

Journal of Cell Biology | ROCKEFELLER UNIV PRESS | Published : 2003

Abstract

The p16INK4a-RB pathway plays a critical role in preventing inappropriate cell proliferation and is often targeted by viral oncoproteins during immortalization. Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is often present in EBV-associated proliferative diseases and is critical for the immortalizing and transforming activity of EBV. Unlike other DNA tumor virus oncoproteins, which possess immortalizing activity, LMP1 does not bind to retinoblastoma tumor suppressor protein, but instead blocks the expression of p16INK4a tumor suppressor gene. However, it has been unclear how LMP1 represses the p16INK4a gene expression. Here, we report that LMP1 promotes the CRM1-dependent nuc..

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