Conference Proceedings

Regulation of mucosal IgA responses in vivo: cytokines and adjuvants.

AJ Husband, DR Kramer, S Bao, RM Sutherland, KW Beagley

Vet Immunol Immunopathol | Published : 1996

Abstract

The predominance of IgA plasma cells at mucosal sites reflects a combination of the selective localisation and vigorous proliferation after extravasation of IgA plasma cell precursors. Experiments are described here which demonstrate that post-extravasation events leading to IgA precursor cell retention, proliferation and antibody secretion are under cytokine control. This has led to investigation of therapeutic interventions to modify cytokine availability to maximise mucosal vaccination responses and correct IgA deficiencies.

University of Melbourne Researchers