Journal article

Coronary Artery Bypass Graft Surgery and Dementia Risk in the Cardiovascular Health Study

Elzbieta Kuzma, Jac Airdrie, Thomas J Littlejohns, Ilianna Lourida, Jo Thompson-Coon, Iain A Lang, Monica Scrobotovici, Evan L Thacker, Annette Fitzpatrick, Lewis H Kuller, Oscar L Lopez, William T Longstreth, Obioha C Ukoumunne, David J Llewellyn



INTRODUCTION: The association between history of coronary artery bypass graft surgery (CABG) and dementia risk remains unclear. METHODS: We conducted a prospective cohort analysis using data on 3155 elderly adults free from prevalent dementia from the US population-based Cardiovascular Health Study (CHS) with adjudicated incident all-cause dementia, Alzheimer disease (AD), vascular dementia (VaD), and mixed dementia. RESULTS: In the CHS, the hazard ratio (HR) for all-cause dementia was 1.93 [95% confidence interval (CI), 1.36-2.74] for those with CABG history compared with those with no CABG history after adjustment for potential confounders. Similar HRs were observed for AD (HR=1.71; 95% CI..

View full abstract


Awarded by National Heart, Lung, and Blood Institute (NHLBI)

Awarded by National Institute on Aging (NIA)

Awarded by National Institute for Health Research

Funding Acknowledgements

Supported by contracts HHSN268201200036C, HHSN268200800007C, N01 HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, and grant HL080295 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided by AG023629, AG20098, AG15928 and HL084443 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at This work was supported by the Mary Kinross Charitable Trust (D.J.L. and E.K.), National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) for the South West Peninsula (I.L., J.T.-C., L.A. L., D.J.L. and O.C.U.) and by NIHR Knowledge Mobilisation Research Fellowship (I.A.L.).