Impact of Experimental Hookworm Infection on the Human Gut Microbiota
Cinzia Cantacessi, Paul Giacomin, John Croese, Martha Zakrzewski, Javier Sotillo, Leisa McCann, Matthew J Nolan, Makedonka Mitreva, Lutz Krause, Alex Loukas
The Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2014
The interactions between gastrointestinal parasitic helminths and commensal bacteria are likely to play a pivotal role in the establishment of host-parasite cross-talk, ultimately shaping the development of the intestinal immune system. However, little information is available on the impact of infections by gastrointestinal helminths on the bacterial communities inhabiting the human gut. We used 16S rRNA gene amplification and pyrosequencing to characterize, for the first time to our knowledge, the differences in composition and relative abundance of fecal microbial communities in human subjects prior to and following experimental infection with the blood-feeding intestinal hookworm, Necator..View full abstract
Awarded by National Health & Medical Research Council (NHMRC) of Australia
Funding from the National Health & Medical Research Council (NHMRC) of Australia [grant 1052938 to C. C., 613718 to P. G., and 1037304 and 1020114 to A. L.], from James Cook University (FMHMS 2013 grants round) and the Isaac Newton Trust/Wellcome Trust ISSF/University of Cambridge Joint Research Grants Scheme to C. C. is gratefully acknowledged.