Secreted Proteomes of Different Developmental Stages of the Gastrointestinal Nematode Nippostrongylus brasiliensis
Javier Sotillo, Alejandro Sanchez-Flores, Cinzia Cantacessi, Yvonne Harcus, Darren Pickering, Tiffany Bouchery, Mali Camberis, Shiau-Choot Tang, Paul Giacomin, Jason Mulvenna, Makedonka Mitreva, Matthew Berriman, Graham LeGros, Rick M Maizels, Alex Loukas
Molecular & Cellular Proteomics | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2014
Hookworms infect more than 700 million people worldwide and cause more morbidity than most other human parasitic infections. Nippostrongylus brasiliensis (the rat hookworm) has been used as an experimental model for human hookworm because of its similar life cycle and ease of maintenance in laboratory rodents. Adult N. brasiliensis, like the human hookworm, lives in the intestine of the host and releases excretory/secretory products (ESP), which represent the major host-parasite interface. We performed a comparative proteomic analysis of infective larval (L3) and adult worm stages of N. brasiliensis to gain insights into the molecular bases of host-parasite relationships and determine whethe..View full abstract
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
This work was supported by a program grant from the National Health and Medical Research Council of Australia (NHMRC), the Wellcome Trust, and the Health Research Council of New Zealand. AL and CC are supported by a NHMRC principal research fellowship and early-career research fellowship, respectively. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.