Proteomic profile of Bithynia siamensis goniomphalos snails upon infection with the carcinogenic liver fluke Opisthorchis uiverrini
Sattrachai Prasopdee, Smarn Tesana, Cinzia Cantacessi, Thewarach Laha, Jason Mulvenna, Rudi Grams, Alex Loukas, Javier Sotillo
Journal of Proteomics | ELSEVIER SCIENCE BV | Published : 2015
UNLABELLED: The snail Bithynia siamensis goniomphalos acts as the first intermediate host for the human liver fluke Opisthorchis viverrini, the major cause of cholangiocarcinoma (CCA) in Northeast Thailand. The undisputed link between CCA and O. viverrini infection has precipitated efforts to understand the molecular basis of host-parasite interactions with a view to ultimately developing new control strategies to combat this carcinogenic infection. To date most effort has focused on the interactions between the parasite and its human host, and little is known about the molecular relationships between the liver fluke and its snail intermediate host. In the present study we analyse the protei..View full abstract
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by National Institute of Allergy and Infectious Disease, National Institutes of Health, USA
Awarded by Thailand Research Fund through the Royal Golden Jubilee Ph.D. Program
This work was supported by project (613669) and program (1037304) grants from the National Health and Medical Research Council of Australia (NHMRC) and a Tropical Medicine Research Collaboration (TMRC) grant from the National Institute of Allergy and Infectious Disease, National Institutes of Health, USA (P50AI098639). AL is supported by a NHMRC principal research fellowship. Funding from Thailand Research Fund through the Royal Golden Jubilee Ph.D. Program (Grant No PHD/0027/2551) to SP and ST is also gratefully acknowledged. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.