Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines
Mark S Pearson, Leon Tribolet, Cinzia Cantacessi, Maria Victoria Periago, Maria Adela Valerio, Amar R Jariwala, Peter Hotez, David Diemert, Alex Loukas, Jeffrey Bethony
Journal of Allergy and Clinical Immunology | MOSBY-ELSEVIER | Published : 2012
Hookworms produce a vast repertoire of structurally and functionally diverse molecules that mediate their long-term survival and pathogenesis within a human host. Many of these molecules are secreted by the parasite, after which they interact with critical components of host biology, including processes that are key to host survival. The most important of these interactions is the hookworm's interruption of nutrient acquisition by the host through its ingestion and digestion of host blood. This results in iron deficiency and eventually the microcytic hypochromic anemia or iron deficiency anemia that is the clinical hallmark of hookworm infection. Other molecular mechanisms of hookworm infect..View full abstract
M. S. Pearson, A. Loukas, and J. Bethony have received research support from the Sabin Vaccine Institute. L. Tribolet has received research support from the Sabin Vaccine Institute and the National Health and Medical Research Council. P. Hotez is president of the Sabin Vaccine Institute. D. Diemert has received research support from the Sabin Vaccine Institute and the Government of The Netherlands. The rest of the authors declare that they have no relevant conflicts of interest.