Journal article
A type IV pilin, pilA, contributes to adherence of Burkholderia pseudomallei and virulence in vivo
AE Essex-Lopresti, JA Boddey, R Thomas, MP Smith, MG Hartley, T Atkins, NF Brown, CH Tsang, IRA Peak, J Hill, IR Beacham, RW Titball
Infection and Immunity | AMER SOC MICROBIOLOGY | Published : 2005
Abstract
The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.