Journal article

Temporally controlled growth factor delivery from a self-assembling peptide hydrogel and electrospun nanofibre composite scaffold

Kiara F Bruggeman, Yi Wang, Francesca L Maclean, Clare L Parish, Richard J Williams, David R Nisbet

NANOSCALE | ROYAL SOC CHEMISTRY | Published : 2017

Abstract

Tissue-specific self-assembling peptide (SAP) hydrogels designed based on biologically relevant peptide sequences have great potential in regenerative medicine. These materials spontaneously form 3D networks of physically assembled nanofibres utilising non-covalent interactions. The nanofibrous structure of SAPs is often compared to that of electrospun scaffolds. These electrospun nanofibers are produced as sheets that can be engineered from a variety of polymers that can be chemically modified to incorporate many molecules including drugs and growth factors. However, their macroscale morphology limits them to wrapping and bandaging applications. Here, for the first time, we combine the bene..

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Grants

Awarded by Australian Research Council


Awarded by NHMRC Career Development Fellowship


Funding Acknowledgements

This research was supported by funding from the National Health and Medical Research Council, Australia and an Australian Research Council Discovery Project (DP130103131). Kiara Bruggeman was supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) Postgraduate Scholarship Doctoral (PGS D) award. Yi Wang was supported by The Australian National University Student PhD Scholarship (International) and an ANU University Research Scholarship (International). Francesca Maclean was supported by an Australian Postgraduate Award. Richard Williams was supported via an Alfred Deakin Research Fellowship. David Nisbet was supported by a NHMRC Career Development Fellowship (APP1050684). C. Parish was supported by a Viertel Charitable foundation senior research fellowship, Australia. Access to the facilities of the Centre for Advanced Microscopy (CAM) with funding through the Australian Microscopy and Microanalysis Research Facility (AMMRF) is gratefully acknowledged.