NORADRENERGIC TRANSMISSION IN ISOLATED GUINEA-PIG INTESTINE FOLLOWING INVIVO ADMINISTRATION OF ANTIBODIES TO DOPAMINE BETA-HYDROXYLASE

Abstract

SummaryThe effectiveness of transmission from noradrenergic nerves supplying the guinea‐pig ileum was evaluated in normal preparations and in preparations taken from animals injected 18 h to 4 days previously with antiserum to dopamine β‐hydroxylase. Degeneration of the nerves following the antiserum was monitored histochemically in the same preparations.A decline in the effectiveness of transmission, which paralleled the degeneration of the nerves, was observed. The earliest effects were detected at 18 h and the greatest effect was found at 2–4 days following the administration of antiserum. Binding of the antibodies has been detected as early as 6 h after injection. It is therefore conclud..